PPF’s biotech pipeline

 

Biotech Corporate Portfolio

  • SOTIO, headquartered in Prague, Czech Republic, is developing autologous dendritic cell-based immunotherapy for oncology indications. It is currently running a global Phase III clinical trial in prostate cancer and multiple Phase II oncology studies.
  • SOTIO was added to PPF’s portfolio in 2012 (press release)
  • Cytune Pharma, headquartered in Nantes, France, is developing super IL-15 fusion protein technology for oncology indications. Its projects are currently in preclinical stage of development.
  • PPF acquired a significant minority stake in Cytune in 2015, followed by an agreement in 2016 on a full buyout at the start of Phase I  (press release)
  • OriBase Pharma, headquartered in Montpellier, France, is developing small molecules and antibodies targeting kinases for oncology indications. Its projects are currently in preclinical stage of development.
  • PPF acquired a majority stake in OriBase in 2014 (press release)
  • Accord Research, headquartered in Prague, Czech Republic, is a full service clinical CRO, providing services for Phases I-IV clinical studies in Europe, US and China.
  • Accord is part of PPF’s biotech portfolio and as a CRO it supports clinical development of the projects in PPF’s portfolio as well as projects of external clients. (Accord website)

SOTIO currently has 10 ongoing clinical trials. In addition, multiple projects in PPF’s portfolio are advancing through preclinical development to enter the clinic soon.

SOTIO Pipeline

Selected Academic Collaborations

Bartholin Institute , Rigshospitalet (Copenhagen, Denmark)
Cordelier Research Center , Immune microenvironment and tumors (Paris, France)
Cordelier Research Center, Laboratory of apoptosis, cancer and immunity (Paris, France)
Cancer Research Centre , Laboratory of apoptosis and tumor progression Nantes-Angers (Nantes, France)
Katholieke Universiteit Leuven, Laboratory of cell death research and therapy (Leuven, Belgium)
Czech Academy of Sciences , Institute of Microbiology (Prague, Czech Republic)
Czech Academy of Sciences , Institute of Molecular Genetics (Prague, Czech republic)
Motol University Hospital (Prague, Czech Republic)
Charles University (Prague, Czech Republic)