List Of Publications

K. Hladíková, S. Partlová, V. Koucký, J. Bouček, J.F. Fonteneau, M. Zábrodský, R. Tachezy, M. Grega, R. Špíšek, A. Fialová

Dysfunction of HPV16-specific CD8+ T cells derived from oropharyngeal tumors is related to the expression of Tim-3 but not PD-1.

Oral Oncol. 2018 Jul;82:75-82. doi: 10.1016/j.oraloncology.2018.05.010. Epub 2018 May 26.

D.P. Funda, J. Goliáš, T. Hudcovic, H. Kozáková, R. Špíšek, L. Palová-Jelínková

Antigen Loading (e.g., Glutamic Acid Decarboxylase 65) of Tolerogenic DCs (tolDCs) Reduces Their Capacity to Prevent Diabetes in the Non-Obese Diabetes (NOD)-Severe Combined Immunodeficiency Model of Adoptive Cotransfer of Diabetes As Well As in NOD Mice

Front Immunol. 2018 Feb 16;9:290. doi: 10.3389/fimmu.2018.00290. eCollection 2018.

E. García-Martínez, M. Smith, A. Buqué, F.Aranda, F.A. de la Peña, A. Ivars, M.S. Cánovas, M. A. V. Conesa, J. Fucikova, R. Špíšek, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy.

Oncoimmunology. 2018 Feb 15;7(6):e1433982. doi: 10.1080/2162402X.2018.1433982. eCollection 2018. Review.

I. Adkins, N. Hradilova, O. Palata, L. Sadilkova, L. Palova-Jelinkova, R. Spisek

High hydrostatic pressure in cancer immunotherapy and biomedicine.

Biotechnol Adv. 2018 May - Jun;36(3):577-582. doi: 10.1016/j.biotechadv.2018.01.015. Epub 2018 Feb 1.

J. Fucikova , L. Kasikova, I. Truxova, J. Laco, P. Skapa , A. Ryska, R. Spisek

Relevance of the chaperone-like protein calreticulin for the biological behavior and clinical outcome of cancer

Immunol Lett. 2018 Jan;193:25-34. doi: 10.1016/j.imlet.2017.11.006. Epub 2017 Nov 23.

J. Fučíková, M. Podrazil, L. Jarolim, P. Bilková, M. Hensler, E. Becht, Z. Gasová, J. Kloucková, J. Kayserová, R. Horváth, A. Fialová, K. Vávrová, K. Sochorová, D. Rožková, R. Špíšek, J. Bartůňková

Phase I/II trial of dendritic cell-based active cellular immunotherapy with DCVAC/PCa in patients with rising PSA after primary prostatectomy or salvage radiotherapy for the treatment of prostate cancer.

Cancer Immunol Immunother. 2018 Jan;67(1):89-100.

C. Vanpouille-Box, C. Lhuillier, L. Bezu, F. Aranda, T. Yamazaki, O. Kepp, J. Fucikova, R. Spisek, S. Demaria, S.C. Formenti, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial watch: Immune checkpoint blockers for cancer therapy.

Oncoimmunology. 2017 Aug 31;6(11):e1373237. doi: 10.1080/2162402X.2017.1373237. eCollection 2017.

R. Mikyskova, M. Indrova, I. Stepanek, I. Kanchev, J. Bieblova, S. Vosahlikova, I. Moserova, I. Truxova, J. Fucikova, J. Bartunkova, R. Spisek, R. Sedlacek, M. Reinis

Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice

Oncoimmunology. 2017 Aug 24;6(12):e1362528. doi: 10.1080/2162402X.2017.1362528. eCollection 2017.

L. Urbanová, N. Hradilová, I. Moserová, Š. Vošahliková, L. Sadílková, M. Henslera, R. Špíšek, I. Adkins

High hydrostatic pressure affects antigenic pool in tumor cells: Implication for dendritic cell-based cancer immunotherapy.

Immunology Letters 187 (2017) 27–34

I. Adkins, L. Sadílková, N. Hradilová, J. Tomala, M. Kovář & R. Špíšek

Severe, but not mild heat-shock treatment induces immunogenic cell death in cancer cells.

Journal OncoImmunology Volume 6, 2017 - Issue 5

N. Hradilová, L. Sadilková, O. Palata, D. Mysikova, H. Mrázková, R. Lischke, R. Špíšek, I. Adkins

Generation of dendritic cell-based vaccine using high hydrostatic pressure for non-small cell lung cancer immunotherapy.

PLOS ONE | DOI:10.1371/journal.pone.0171539

K. Dáňová, A. Grohová, P. Strnadová, D.P. Funda, Z. Šumník, J. Lebl, O. Cinek, Š. Průhová, S. Koloušková, B. Obermannová, L. Petruželková, A. Šedivá, P. Fundová, K. Buschard, R. Špíšek, L. Palová-Jelínková.

Tolerogenic Dendritic Cells from Poorly Compensated Type 1 Diabetes Patients Have Decreased Ability To Induce Stable Antigen-Specific T Cell Hyporesponsiveness and Generation of Suppressive Regulatory T Cells.

J Immunol. 2017 Jan 15;198(2):729-740.

J. Fučíková, I. Truxová, M. Hensler, E. Becht, L. Kasíková, I. Moserová, S. Vošáhliková, J. Kloučková, S.E. Church, I. Cremer, O. Kepp, G. Kroemer, L. Galluzzi, C. Salek, R. Špíšek

Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients.

Blood. 2016 Dec 29;128(26):3113-3124. doi: 10.1182/blood-2016-08-731737. Epub 2016 Nov 1.

I. Truxová, M. Hensler, P. Skapa, M. J. Halaska, J. Laco, A. Ryška, R. Špíšek, J. Fučíková.

Rationale for the Combination of Dendritic Cell-Based Vaccination Approaches With Chemotherapy Agents.

Int Rev Cell Mol Biol. 2017;330:115-156.

I. Moserová, I. Truxová, A.D. Garg, J. Tomala, P. Agostinis, P.F. Cartron, S. Vošáhlíková, M. Kovář, R. Špíšek, J. Fučíková

Caspase-2 and oxidative stress underlie the immunogenic potential of high hydrostatic pressure-induced cancer cell death.

Oncoimmunology. 2016 Nov 18;6(1):e1258505.

D. Myšíková, I. Adkins, N. Hradilová, O. Palata, J. Šimonek, J. Pozniak, J. Kolařík, A. Skallová-Fialová, R. Špíšek, R. Lischke

Case-Control Study: Smoking History Affects the Production of Tumor Antigen-Specific Antibodies NY-ESO-1 in Patients with Lung Cancer in Comparison with Cancer Disease-Free Group.

J Thorac Oncol. 2016 Oct 25. pii: S1556-0864(16)31176-5.

E. Vacchelli, N. Bloy, F. Aranda, A. Buqué, I. Cremer, S. Demaria, A. Eggermont, Ś.C. Formenti, W.H. Fridman, J. Fučíková, J. Galon, R. Špíšek, E. Tartour, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Immunotherapy plus radiation therapy for oncological indications.

Oncoimmunology. 2016 Jul 25;5(9):e1214790. eCollection 2016.

K. Kloudová, H. Hromádková, S. Partlová, T. Brtnický, L. Rob, J. Bartůňková, M. Hensler, M.J. Halaška, R. Špíšek, A. Fialová

Expression of tumor antigens on primary ovarian cancer cells compared to established ovarian cancer cell lines.

Oncotarget. 2016 Jul 19;7(29):46120-46126.

A. Buqué, N. Bloy, F. Aranda, I. Cremer, A. Eggermont, W.H. Fridman, J. Fučíková, J. Galon, R. Špíšek, E. Tartour, L. Zitvogel, G. Kroemer, L Galluzzi

Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy.

Oncoimmunology. 2016 Mar 10;5(6):e1149674.

J. Fučíková, E. Becht, K. Iribarren, J. Goc, R. Remark, D. Damotte, M. Alifano, P. Devi, J. Biton, C. Germain, A. Lupo, W. H. Fridman, M. C. Dieu-Nosjean, G. Kroemer, C. Sautès-Fridman, I. Cremer

Calreticulin Expression in Human Non-Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis.

Cancer Res. 2016 Feb 3. [Epub ahead of print]

J. Fučíková, J. Bartůňková, R. Špíšek

The Concept of Immunogenic Cell Death in Antitumor Immunity

Klin Onkol. 2015;28 Suppl 4:4S48-55.

S. Partlová, J. Bouček, K. Kloudová, M. Zábrodský, R. Špíšek, A. Fialová

Immune System in Patients with Head and Neck Carcinoma.

Klin Onkol. 2015;28 Suppl 4:4S86-94.

R. Mikyšková, I. Štěpánek, M. Indrová, J. Bieblová, J. Šímová, I. Truxová, I. Moserová, J. Fučíková, J. Bartůňková, R. Špíšek, M. Reiniš

Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy.

Int J Oncol. 2016 Mar;48(3):953-64. doi: 10.3892/ijo.2015.3314. Epub 2015 Dec 29.

M. Hensler, I. Vančurová, E. Becht, O. Palata, P. Strnad, P. Tesařová, M. Čabiňaková, D. Švec, M. Kubista, J. Bartůňková, R. Špíšek, L. Sojka

Gene expression profiling of circulating tumor cells and peripheral blood mononuclear cells from breast cancer patients.

Oncoimmunology. 2015 Dec 10;5(4):e1102827. eCollection 2016.

J. Pol, A. Buqué, F. Aranda, N. Bloy, I. Cremer, A. Eggermont, P. Erbs, J. Fučíková, J. Galon, J. M. Limacher, X. Preville, C. Sautès-Fridman, R. Špíšek, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch-Oncolytic viruses and cancer therapy.

Oncoimmunology. 2015 Dec 8;5(2):e1117740. eCollection 2016.

E. Vacchelli, F. Aranda, N. Bloy, A. Buqué, I. Cremer, A. Eggermont, W.H. Fridman, J. Fučíková, J. Galon, R. Špíšek, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch-Immunostimulation with cytokines in cancer therapy.

Oncoimmunology. 2015 Dec 8;5(2):e1115942. eCollection 2016.

A. D. Garg, L. Galluzzi, L. Apetoh, T. Baert, R. B. Birge, J. M. Bravo-San Pedro, K. Breckpot, D. Brough, R. Chaurio, M. Cirone, A. Coosemans, P. G. Coulie, D. De Ruysscher, L. Dini, P. de Witte, A. M. Dudek-Peric, A. Faggioni, J. Fucikova, U.S. Gaipl, J. Golab, M. L. Gougeon, M. R. Hamblin, A. Hemminki, M. Herrmann, J.W. Hodge, O. Kepp, G. Kroemer, D. V. Krysko, W. G. Land, F. Madeo, A. A. Manfredi, S. R. Mattarollo, C. Maueroder, N. Merendino, G. Multhoff, T. Pabst, J.E. Ricci, C. Riganti, E. Romano, N. Rufo, M. J. Smyth, J. Sonnemann, R. Spisek, J. Stagg, E. Vacchelli, P. Vandenabeele, L. Vandenberk, B. J. Van den Eynde, S. Van Gool, F. Velotti, L. Zitvogel, P. Agostinis

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Front Immunol. 2015 Nov 20;6:588. doi: 10.3389/fimmu.2015.00588. eCollection 2015.

K. Iribarren, N. Bloy, A. Buqué, I. Cremer, A. Eggermont, W.H. Fridman, J. Fučíková, J. Galon, R. Špíšek, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy.

Oncoimmunology. 2015 Sep 2;5(3):e1088631. eCollection 2016.

J. Fučíková, I. Moserova, L. Urbanova,L. Bezu, O. Kepp, I. Cremer, C. Šálek, P. Strnad, G. Kroemer, L. Galluzzi, R. Špíšek

Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer

Front Immunol. 2015 Aug 7;6:402. doi: 10.3389/fimmu.2015.00402. eCollection 2015. Review

Jitka Fučíková, Irena Moserová, Linda Urbanová, Lucillia Bezu, Oliver Kepp, Isabelle Cremer, Cyril Salek, Pavel Strnad, Guido Kroemer, Lorenzo Galluzzi and Radek Špíšek

Prognostic and predictive value of DAMPs and DAMP-associated processes in cancer

K. Dáňová, A. Klapetková, J. Kayserová, A. Šedivá, R. Špíšek, L.P. Jelínková

NF-κB, p38 MAPK, ERK1/2, mTOR, STAT3 and increased glycolysis regulate stability of paricalcitol/dexamethasone-generated tolerogenic dendritic cells in the inflammatory environment.

Oncotarget. 2015 Jun 10;6(16):14123-38.

M. Podrazil, R. Horváth, E. Becht, D. Rožková, P. Bílková, K. Sochorová, H. Hromádková, J. Kayserová, K. Vávrová, J. Laštovička, P. Vrabcová, K. Kubacková, Z. Gasová, L. Jarolim, M. Babjuk, R. Śpíšek, J. Bartůňková, J. Fučíková

Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer.

Oncotarget. 2015 May 29. [Epub ahead of print]

F. Aranda, A. Buqué, N. Bloy, F. Castoldi, A. Eggermont, I. Cremer, W.H. Fridman, J. Fučíková, J. Galon, R. Špíšek, E. Tartour, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Adoptive cell transfer for oncological indications.

Oncoimmunology. 2015 May 5;4(11):e1046673. eCollection 2015 Nov. Review.

L. Bezu, L. C. Gomes-de-Silva, H. Dewitte, K. Breckpot, J. Fučíková, R. Špíšek, L. Galluzzi, O. Kepp, G. Kroemer

Combinatorial strategies for the induction of immunogenic cell death.

Front Immunol. 2015 Apr 24;6:187. doi: 10.3389/fimmu.2015.00187. eCollection 2015.

N. Bloy, A. Buqué, F. Aranda, F. Castoldi, A. Eggermont, I. Cremer, C. Sautès-Fridman, J. Fučiková, J. Galon, R. Špíšek, E. Tartour, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial watch: Naked and vectored DNA-based anticancer vaccines.

Oncoimmunology. 2015 Apr 2;4(5):e1026531. eCollection 2015 May.

J. Pol, E. Vacchelli, F. Aranda, F. Castoldi, A. Eggermont, I. Cremer, C. Sautès-Fridman, J. Fučíková, J. Galon, R. Špíšek, E. Tartour, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy.

Oncoimmunology. 2015 Mar 2;4(4):e1008866. eCollection 2015 Apr. Review.

A. Buqué, N. Bloy, F. Aranda, F. Castoldi, A. Eggermont, I. Cremer, W.H. Fridman, J. Fučíková, J. Galon, A. Marabelle, R. Špišek, E. Tartour, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications.

Oncoimmunology. 2015 Mar 2;4(4):e1008814. eCollection 2015 Apr. Review.

S. Partlová, J. Bouček, K. Kloudová, E Lukešová, M. Zábrodský, M. Grega, J. Fučíková, I. Truxová, R. Tachezy, R. Špíšek, A. Fialová

Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma.

Oncoimmunology. 2015 Jan 30;4(1):e965570. eCollection 2015.

Irena Adkins, Jitka Fučíková, Abhishek D. Garg, Patrizia Agostinis, Radek Špíšek

Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy

OncoImmunology Volume 3, Issue 12, 2014, DOI:10.4161/21624011.2014.968434

N. Bloy, J. Pol, F. Aranda, A. Eggermont, I. Cremer, W.H. Fridman, J. Fučíková, J. Galon, E. Tartour, R. Spisek, M.V. Dhodapkar, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial watch: Dendritic cell-based anticancer therapy.

Oncoimmunology. 2014 Dec 21;3(11):e963424. eCollection 2014.

L. Galluzzi, E. Vacchelli, J. Bravo-San Pedro, A. Buqué, L. Senovilla, E.E. Baracco, N. Bloy, F. Castoldi, J. Abastado, P. Agostinis, R.N. Apte, F. Aranda, M. Ayyoub, P. Beckhove, J. Blay, L. Bracci, A. Caignard, C. Castelli, F. Cavallo, E. Celis, V.Cerundolo, A. Clayton, M.P. Colombo, L. Coussens, M. V. Dhodapkar, A. M. Eggermont, D.T. Fearon, W. H. Fridman, J. Fučíková, D.I. Gabrilovich, J. Galon, A. Garg, F. Ghiringhelli, G. Giaccone, E. Gilboa, S. Gnjatic, A. Hoos, A. Hosmalin, D. Jäger, P. Kalinski, K. Kärre, O. Kepp, R. Kiessling, J. M. Kirkwood, E. Klein, A. Knuth, C. E. Lewis, R. Liblau, M. T. Lotze, E. Lugli, J. Mach, F. Mattei, D. Mavilio, I. Melero, C. J. Melief, E. A. Mittendorf, L. Moretta, A. Odunsi, H. Okada, A. K. Palucka, M. E. Peter, K. J. Pienta, A. Porgador, G. C. Prendergast, G. A. Rabinovich, N. P. Restifo, N. Rizvi, C. Sautès-Fridman, H. Schreiber, B. Seliger, H. Shiku, B. Silva-Santos, M. J. Smyth, D. E. Speiser, R. Spisek, P. K. Srivastava, J. E.Talmadge , E. Tartour, S. H. Van Der Burg , ´B. J. Van Den Eynde, H. Vile R, Wagner, J. S. Weber, T. L. Whiteside, J. D. Wolchok, L. Zitvogel, W. Zou, G. Kroemer

Classification of current anticancer immunotherapies.

Oncotarget. 2014 Dec 18. [Epub ahead of print]

O. Kepp, L. Senovilla, I. Vitale, E. Vacchelli, S. Adjemian, P. Agostinis, L. Apetoh, F. Aranda, V. Barnaba, N. Bloy, L. Bracci, K. Breckpot, D. Brough, A. Buqué, M.G. Castro, M. Cirone, M. I. Colombo, I. Cremer, S. Demaria, L. Dini, A. G. Eliopoulos, A. Faggioni, S.C. Formenti, J. Fučíková, L. Gabriele, U. S. Gaipl, J. Galon, A. Garg, F. Ghiringhelli, N. A. Giese, Z. S. Guo, A. Hemminki, M. Herrmann, J.W. Hodge, S. Holdenrieder, J. Honeychurch, H. M. Hu, X. Huang, T. M. Illidge, K. Kono, M. Korbelik, D. V. Krysko, S. Loi, P.R. Lowenstein, E. Lugli, Y. Ma, F. Madeo, A. A. Manfredi, I. Martins, D. Mavilio, L. Menger, N. Merendino, M. Michaud, G. Mignot, K. L. Mossman, G. Multhoff, R. Oehler, F. Palombo, T. Panaretakis, J. Pol, E. Proietti, J. E. Ricci, C. Rigant, P. Rovere-Querini, A. Rubartelli, A. Sistigu, M. J. Smyth, J. Sonnemann, R. Špišek, J. Stagg, A.Q. Sukkurwala, E. Tartour, A. Thorburn, S. H. Thorne, P. Vandenabeele, F. Velotti, S. T. Workenhe, H. Yang, W. X. Zong, L. Zitvogel, G. Kroemer, L. Galluzzi

Consensus guidelines for the detection of immunogenic cell death.

Oncoimmunology. 2014 Dec 13;3(9):e955691. eCollection 2014.

T. Brtnický, A. Fialová, J. Laštovička, L. Rob, R. Špíšek

Clinical relevance of regulatory T cells monitoring in the peripheral blood of ovarian cancer patients.

Hum Immunol. 2014 Dec 13. pii: S0198-8859(14)00504-7. doi: 10.1016/j.humimm.2014.12.004. [Epub ahead of print]

I. Adkins, J. Kamanova, A. Kocourkova, M. Svedova, J. Tomala, H. Janova, J. Masin, B. Chladkova, L. Bumba, M. Kovar, P.J. Ross, L. Tuckova, R. Spisek, K.H. Mills, P. Sebo

Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.

PLoS One. 2014 Aug 1;9(8):e104064. doi: 10.1371/journal.pone.0104064. eCollection 2014.

I. Truxová, K. Pokorná, K. Kloudová, S. Partlová, R. Špíšek, J. Fučíková

Day 3 Poly (I:C)-activated dendritic cells generated in CellGro for use in cancer immunotherapy trials are fully comparable to standard Day 5 DCs.

Immunol Lett. 2014 Jul;160(1):39-49. doi: 10.1016/j.imlet.2014.03.010. Epub 2014 Apr 12.

J. Kayserová, J. Včeláková, K. Štechová, E. Dudková, H. Hromádková, Z. Sumnik, S. Koloušková, R. Špíšek, A. Šedivá

Decreased dendritic cell numbers but increased TLR9-mediated interferon-alpha production in first degree relatives of type 1 diabetes patients.

Clin Immunol. 2014 Jul;153(1):49-55. doi: 10.1016/j.clim.2014.03.018. Epub 2014 Apr 5

Iva Truxová, Kateřina Pokorná, Kamila Kloudová, Simona Partlová, Radek Špíšek, Jitka Fučíková

Day 3 Poly (I:C)-activated dendritic cells generated in CellGro for use in cancer immunotherapy trials are fully comparable to standard Day 5 DCs.

Immunoll Letters 10.1016/j.imlet.2014.03.010

J. Fučíková, I.Moserová, I. Truxová, I. Heřmanová, I. Vančurová, S. Partlová, A. Fialová, L. Sojka, P.F. Cartron, M. Houska, L. Rob, J. Bartůňková, R. Špíšek

High hydrostatic pressure induces immunogenic cell death in human tumor cells.

Int J Cancer. 2014 Sep 1;135(5):1165-77. doi: 10.1002/ijc.28766. Epub 2014 Feb 20.

Jitka Fučíková, Irena Moserová, Iva Truxová, Ivana Heřmanová, Irena Vančurová, Simona Partlová, Anna Fialová, Luděk Sojka, P.F. Cartron, M. Houska, Lukáš Rob, Jiřina Bartůňková, Radek Špíšek

High hydrostatic pressure induces immunogenic cell death in human tumor cells

Int J Cancer. 2014 Sep 1;135(5):1165-77.

I. Adkins, L. Sadilková, L. Palová-Jelínková

Bacterial toxins in cancer immunotherapy

Forum on Immunopathological Diseases and Therapeutics, 4(3–4):219–239 (2013), DOI: 10.1615/ForumImmunDisTher.2014008368

Erika Vacchelli, Ilio Vitale, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fučíková, Isabelle Cremer, Jérôme Galon, Eric Tartour, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi

Trial watch: Dendritic cell-based interventions for cancer therapy.

Oncoimmunology 2013 Oct 1;2(10):e25771. Epub 2013 Jul 29.

Anna Fialová, Simona Partlová, Luděk Sojka, Hana Hromádková, Tomáš Brtnický, Jitka Fučíková, P. Kocian, Lukáš Rob, Jiřina Bartůňková, Radek Špíšek

Dynamics of T-cell infiltration during the course of ovarian cancer: the gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells.

Int J Cancer 2013;132: 1070-9.

Ashley J. Knights, Jitka Fučíková, Anupama Pasam, Sandra Koernig, Jonathan Cebon

Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy.

Cancer Immunol Immunother. 2013 Feb 62(2):321-35.

Oliver Klein, Lisa M Ebert, Damien Zanker, Katherine Woods, Bee Shin Tan, Jitka Fučíková, Andreas Behren, Ian D. Davis, Eugene Maraskovsky, Weisan Chen, Jonathan Cebon

Flt3 ligand expands CD4+ FoxP3+ regulatory T cells in human subjects.

European Journal of Immunology 2013 Feb;43 (2):533-9.

Jitka Fučíková, Daniela Rožková, Hana Ulčová, Vít Budinský, Klára Sochorová, Kateřina Pokorná, Jiřina Bartůňková and Radek Špíšek

Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials.

Journal of Translational Medicine 2011

Petr Kocián, Monika Šedivcová, Jan Drgáč, Kateřina Černá, Jiří Hoch, Roman Kodet, Jiřina Bartůňková, Radek Špíšek, Anna Fialová

Tumor-infiltrating lymphocytes and dendritic cells in human colorectal cancer: their relationship to KRAS mutational status and disease recurrence.

Hum Immunol 2011;72: 1022-8.

Rudolf Horváth, Daniela Rožková, Jan Lašt'ovička, Andrea Poloučková,Petr Sedláček, Anna Šedivá, Radek Špíšek

Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease.

Clin Exp Immunol. Oct 2011;166: 26-33.

Jitka Fučíková, Petra Králíkova, Anna Fialová, Tomáš Brtnický, Lukáš Rob, Jiřina Bartůňková,Radek Špíšek

Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response

Cancer Res. 2011 Jul (15;71(14):4821-33. doi: 10.1158/0008-5472.CAN-11-0950.)

Jitka Fučíková, Petra Králíková, Anna Fialová, Tomáš Brtnický, Lukáš Rob, Jiřina Bartůňková, Radek Špíšek

Human tumor cells killed by anthracyclines induce a tumor-specific immune response.

Cancer Res 2011;71: 4821-33.

Daniela Rožková, Linda Novotná, Robert Pytlík, Ivana Hochová, Tomáš Kozák, Jiřina Bartůňková, Radek Špíšek

Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation.

International Journal of Cancer 2010 ;126: 1132-43.

Klára Sochorová, Vít Budinský, Daniela Rožková, Zuzana Tobiasová, Sylvie Dusilová-Sulková, Radek Špíšek, Jiřina Bartůňková

Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells.

Clin Immunol 2009;133: 69-77.

A. Kučera, K. Pycha, P. Pajer, R. Špíšek, R. Škaba

Dendritic cell-based immunotherapy induces transient clinical response in advanced rat fibrosarcoma - comparison with preventive anti-tumour vaccination.

Folia Biol (Praha) 2009;55: 119-25.

Daniela Rožková, Hana Tišerová, Jitka Fučíková, Jan Lašt'ovička, Michal Podrazil, Hana Ulčová, Vít Budínský, Jana Prausová, Zdeněk Linke, Ivo Minárik, Anna Šedivá, Radek Špíšeka, Jiřina Bartůňková et al.

FOCUS on FOCIS: combined chemo-immunotherapy for the treatment of hormone-refractory metastatic prostate cancer.

Clinical Immunology 2009;131: 1-10.

Sayuri Yamazaki, Anthony J. Bonito, Radek Špíšek, Madhav Dhodapkar, Kayo Inaba, Ralph M. Steinman

Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors.

Blood 2007;110: 4293-302.

Radek Špíšek, Madhav V. Dhodapkar

Towards a better way to die with chemotherapy: role of heat shock protein exposure on dying tumor cells.

Cell Cycle 2007;6: 1962-5.

Radek Špíšek, Anna Charalambous, Amitabha Mazumder, David H. Vesole, Sundar Jagannath, Madhav V. Dhodapkar

Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications.

Blood 2007;109: 4839-45.

Radek Špíšek, Anjli Kukreja, Lin-Chi Chen, Phillip Matthews, Amitabha Mazumder, David Vesole, Sundar Jagannath, Henry A. Zebroski, Andrew J.G. Simpson, Gerd Ritter, Brian Durie, John Crowley et al.

Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy.

J Exp Med 2007;204: 831-40.

Klára Sochorová, Rudolf Horváth, Daniela Rožková, Jiří Litzman, Jiřina Bartůňková, Anna Šedivá, Radek Špíšek

Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia.

Blood 2007;109: 2553-6.

Zuzana Tobiásová, Dagmar Pospíšilová, Ashley M. Miller, Ivo Minárik, Klára Sochorová, Radek Špíšek, Lukáš Rob, Jiřina Bartůňková

In vitro assessment of dendritic cells pulsed with apoptotic tumor cells as a vaccine for ovarian cancer patients.

Clin Immunol 2007;122: 18-27.

Radek Špíšek

Immunoprevention of cancer: time to reconsider timing of vaccination against cancer.

Expert Rev Anticancer Ther 2006;6: 1689-91.

Daniela Rožková, Rudolf Horváth, Jiřina Bartůňková, Radek Špíšek

Glucocorticoids severely impair differentiation and antigen presenting function of dendritic cells despite upregulation of Toll-like receptors.

Clinical Immunology 2006;120: 260-71.

Radek Špíšek, Madhav V. Dhodapkar

Immunoprevention of cancer.

Hematol Oncol Clin North Am 2006;20: 735-50.

Radek Špíšek, Zdena Gašová, Jiřina Bartůňková

Maturation state of dendritic cells during the extracorporeal photopheresis and its relevance for the treatment of chronic graft-versus-host disease.

Transfusion 2006;46: 55-65.

Evžen Bouřa, D. Liebl, Radek Špíšek, Jan Frič, M. Marek, J. Stokrová, Vladimír Holán, Jitka Forstová

Polyomavirus EGFP-pseudocapsids: analysis of model particles for introduction of proteins and peptides into mammalian cells.

FEBS Lett 2005;579: 6549-58.

Lenka Palová-Jelínková, Daniela Rožková, Barbara Pecharová, Jiřina Bártová, Anna Šedivá, Helena Tlaskalová-Hogenová, Radek Špíšek, Ludmila Tučková

Gliadin fragments induce phenotypic and functional maturation of human dendritic cells.

J Immunol 2005;175: 7038-45.

Dagmar Pospíšilová, Jiřina Borovičková, Daniela Rožková, Jan Starý, Daniela Seifertová, Zuzana Tobiásová, Radek Špíšek, Jiřina Bartůňková

Methods of dendritic cell preparation for acute lymphoblastic leukemia immunotherapy in children. Med Oncol 2005;22: 79-88.

Medical Oncology 2005;22: 79-88.

Radek Špíšek; Jitka Brazová; Daniela Rožková; Kateřina Zapletalová; Anna Šedivá; Jiřina Bartůňková

Maturation of dendritic cells by bacterial immunomodulators.

Vaccine 2004;22: 2761-8.

Radek Špíšek, Gwenola Bougras, Frederic Ebstein, Delphine Masse, Khaled Meflah, Dorian McIlroy, Marc Gregoire

Transient exposure of dendritic cells to maturation stimuli is sufficient to induce complete phenotypic maturation while preserving their capacity to respond to subsequent restimulation.

Cancer Immunol Immunother 2003;52: 445-54.

M. Grégoire, C. Ligeza-Poisson, N. Juge-Morineau, R. Špíšek

Anti-cancer therapy using dendritic cells and apoptotic tumour cells: pre-clinical data in human mesothelioma and acute myeloid leukaemia.

Vaccine 2003;21: 791-4.

David Favre, Véronique Blouin, Nathalie Provost, Radek Špíšek, Françoise Porrot, Delphine Bohl, Frederic Marmé, Yan Chérel, Anna Salvetti, Bruno Hurtrel, Jean-Michel Heard, Yves Rivière, Philippe Moullier et al.

Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus.

J Virol 2002;76: 11605-11.

Radek Špíšek, Patrice Chevallier, Nadine Morineau, Noël Milpied, Herve Avet-Loiseau, Jean-Luc Harousseau, Khaled Meflah, Marc Gregoire

Induction of leukemia-specific cytotoxic response by cross-presentation of late-apoptotic leukemic blasts by autologous dendritic cells of nonleukemic origin.

Cancer Res 2002;62: 2861-8.

Dagmar Pospíšilová, Jiřina Borovičková, Andrea Poloučková, Radek Špíšek, Anna Šedivá, Ondřej Hrušák, Jan Starý, Jiřina Bartůňková

Generation of functional dendritic cells for potential use in the treatment of acute lymphoblastic leukemia.

Cancer Immunol Immunother 2002 April ;51: 72-8.

Radek Špíšek, Laurent Bretaudeau, Isabelle Barbieux I, Khaled Meflah, Marc Gregoire

Standardized generation of fully mature p70 IL-12 secreting monocyte-derived dendritic cells for clinical use.

Cancer Immunol Immunother 2001 October;50: 417-27.
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