March 12, 2024
Source: Press Release, Prague and Boston
In a poster at the conference, SOTIO will present data from the company’s BOXR platform of enhanced T cell therapies. SOTIO leveraged the BOXR technology to design CAR T cells enhanced with transgenes encoding GOT2 (glutamine oxaloacetate transaminase) and TIGAR (TP53-induced glycolysis and apoptosis regulator), both of which are believed to play a role in T cell fitness in the hostile solid tumor microenvironment. Compared to unmodified CAR T cells and CAR T cells enhanced with GOT2 solely, CAR T cells enhanced with GOT2 and TIGAR showed better tumor infiltration, lower levels of exhaustion, and superior anti-tumor activity in a mouse model of solid tumors.
SOTIO’s lead candidate from the BOXR platform, BOXR1030 — a GOT2-enhanced CAR T-cell therapy — is currently being evaluated in a Phase 1/2 study for patients with solid tumors.
A second study to be presented at the meeting investigated the immunostimulatory effects of PARP inhibitors in models of epithelial ovarian cancer, determining their activity on molecular and cellular pathways to inform better combination therapy strategies with cancer immunotherapies.
Poster details are as follows:
Title: “Dual expression of exogenous glutamine oxaloacetate transaminase (GOT2) and TP53-induced glycolysis and apoptosis regulator (TIGAR) enhance CAR T cell activity in preclinical solid tumor models”
Presenting Author: Amy Jensen-Smith
Abstract Number: 4012
Date & Time: April 9, 2024, 9:00 a.m. – 12:30 p.m. PT
Title: “Immunological control by PARP inhibitors for successful immunotherapy in metastatic ovarian carcinoma”
Presenting Author: Peter Holicek
Abstract Number: 5278
Date & Time: April 9, 2024, 1:30 p.m. – 5:00 p.m. PT
Presentation materials will be available after presentations conclude here.
